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KMID : 1134820070360040411
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Journal of the Korean Society of Food Science and Nutrition
2007 Volume.36 No. 4 p.411 ~ p.418
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Effect of Pine Needle Water Extract on Cadmium-Induced Oxidative Stress in Rats
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Jang Joo-Yeun
Kim Myung-Joo
Lee Mi-Kyung
Kim Duk-Jin
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Abstract
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Oxidative stress can play a key role in cadmium (Cd)-induced dysfunction. The present study examined the effect of pine needle water extract (PN) on Cd-induced oxidative stress in rats. Sprague-Dawley male rats were divided into three groups: normal group, Cd control group (Cd) and PN-administered Cd group (Cd-PN). CdCl₂ in 0.9% NaCl was administered orally with a dose of 5 ㎎/㎏ of body weight/week, while the PN was administered orally with a dose of 1.26 g/㎏ of body weight/day. Body weight gain was not different between groups, whereas food intakes were significantly lower in the Cd-PN group than in normal or Cd group. Relative liver weight was significantly increased by cadmium administration compared to the normal group. Hepatic cytochrome P450 was significantly lower in Cd and Cd-PN groups than in normal group, while xanthine oxidase and alcohol dehydrogenase activities were significantly higher in the Cd-PN group than in normal or Cd group. Increased hepatic superoxide dismutase, monoamine oxidase, catalase, and glutathione peroxidase activities by cadmium administration were significantly decreased by PN supplement. PN did not affect the hepatic glutathione content in cadmium-administered rats; however, PN significantly lowered the hepatic lipid peroxide level and plasma alanine transferase activity compared to the Cd control group. These results suggest that the PN may alleviate Cd-induced oxidative stress without hepatotoxicity
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KEYWORD
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cadmium, pine needle water extract, oxidative stress, hepatotoxicity
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